JOURNAL BIOLOGIA CELULAR E MOLECULAR
Horizontal Transmission of Clonal Cancer Cells Causes Leukemia in Soft-Shell Clams
Apresentadores: Danielle Mascarenhas e Carlos A. C. Lima
Tutor: Profa. Letícia F. Archangelo
Outbreaks of fatal leukemia-like cancers of marine bivalves throughout the world have led to massive population loss. The cause of the disease is unknown. We recently identified a retrotransposon, Steamer, that is highly expressed and amplified to high copy number in neoplastic cells of soft-shell clams (Mya arenaria). Through analysis of Steamer integration sites, mitochondrial DNA single nucleotide polymorphisms (SNPs), and polymorphic microsatellite alleles, we show that the genotypes of neoplastic cells do not match those of the host animal. Instead, neoplastic cells from dispersed locations in New York, Maine, and Prince Edward Island (PEI), Canada, all have nearly identical genotypes that differ from those of the host. These results indicate that the cancer is spreading between animals in the marine environment as a clonal transmissible cell derived from a single original clam. Our findings suggest that horizontal transmission of cancer cells is more widespread in nature than previously supposed.
SEGUNDA FEIRA 27.04.2015 às 16:30 hs
Anfiteatro Pedreira de Freitas – Prédio Central – FMRP
Artigo na íntegra: Aqui.